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Inside earlier analysis, squalene has been shown to minimize MPO while increasing HO-step 1 gene phrase inside the person neutrophils and monocytes addressed with LPS. MPO try an individual healthy protein discover primarily inside the neutrophil azurophilic granules and you may monocyte lysosomes [85, 86, 87]. The outcome reveal that immediately after 18 h away from medication that have fifty Meters squalene, the brand new mRNA number of MPO inside the LPS-treated individual monocytes and you will neutrophils diminished (P 0.001).
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